P14
The role of γδ T cells in the tumor microenvironment of colorectal cancer
Research Focus
While CD4+ and CD8+ T cells are well studied, much less is known about the function of γδT cells in the context of CRC pathogenesis. Considering that γδT cells do not require conventional MHC-dependent antigen presentation, P14 proposes that γδT cells influence tumor progression. γδT cells were found to be enriched at the invasive front of colorectal tumors while demonstrating efficient killing of CRC cells in vitro. Employing primary and metastatic patient-derived organoids and human γδT cells from healthy donors and tumor patients, γδT cell function will be explored in ex vivo co-culture and in humanized mice.
Main Collaborations
- P07 Berlin/Groß: Specific role(s) of the inflammasome in the TME of primary and metastasized sporadic CRC:
- P10 Bengsch/Feuerstein: Targeting the intra-metastatic microbiome in colorectal cancer:
- P16 Fichtner-Feigl/Imkeller: The role of primary-CRC-derived adaptive immune cells in anti-metastasis immunity:
- P18 Buchholz/Farin: Identifying and overcoming CAR T cell barriers in the colorectal carcinoma microenvironment:
- S02 Reiss/Ritter: Spatial profiling of the tumor microenvironment in CRC:
- S03 Börries/Gupta: Research Information Infrastructure, Data Management and Bioinformatics Core:
