Research projects The Research Projects of TRR 417 Thematic Clustering Project Collaborations CAF and ECM Cluster P01 Greten: Modulating CAF plasticity to enable immunotherapy of colorectal cancer P02 Büttner/Flinner: Multi modal prediction of therapy response for rectal cancer patients P03 Briquez/Fichtner-Feigl/Reuten: Metastasis predisposing extracellular matrix architecture in colorectal cancer P04 Farin/Stemmler: Mapping the CAF subtype-dependent reciprocal signaling in the CRC niche P05 Neufert: The role of LIFR signaling in CAFs in CRC P06 Günther/Naschberger: Impact of vascular plasticity on therapy responses in CRC Soluble Mediators P07 Berlin/Groß: Specific role(s) of the inflammasome in the TME of primary and metastasized sporadic CRC P08 Weigert: The role of IL-38 in shaping tumor-promoting versus protective inflammation in colorectal cancer P09 Koop/Neurath: Unraveling the Role of Stromal IL-36R Signaling in Colorectal Tumorigenesis P10 Bengsch/Feuerstein: Targeting the intra-metastatic microbiome in colorectal cancer P11 Arkan/Tatarova: Role of microbial amino acid metabolism on chemotherapy response in CRC P12 Rosshart: Identification of immunomodulatory microbial metabolites as novel therapeutics for advanced CRC Immune Cell Cluster P13 Müller/Zundler: Modulation of CRC development and progression by GPR15L-dependent effects on lymphocyte infiltration and the intestinal microbiota P14 Kesselring/Minguet: The role of γδ T cells in the tumor microenvironment of colorectal cancer P15 Hildner: Tumor stroma-derived signals impair cDC1-dependent checkpoint inhibition as a potential resistance mechanism of colorectal cancer immunotherapy P16 Fichtner-Feigl/Imkeller: The role of primary-CRC-derived adaptive immune cells in anti-metastasis immunity P17 Ziegler: STAT3-controlled cross-dressing of dendritic cells in anti-tumor immunity P18 Buchholz/Farin: Identifying and overcoming CAR T cell barriers in the colorectal carcinoma microenvironment P19 Wiegering: Targeting colorectal liver metastasis by overcoming MYC-induced immune evasion Central Projects S01 Berlin/Greten/Naschberger: Human tumor organoid biobanks for preclinical validation S02 Reiss/Ritter: Spatial profiling of the tumor microenvironment in CRC S03 Börries/Gupta: Research Information Infrastructure, Data Management and Bioinformatics Core IRTG Farin/Feuerstein/Günther: Integrated Research Training Group (IRTG)
