P07
Specific role(s) of the inflammasome in the TME of primary and metastasized sporadic CRC
Research Focus
P07 will specifically examine the contribution of inflammasomes that act as intracellular danger-sensing complex controlling release of pro-inflammatory cytokines belonging to the IL-1 family. Various genetic models targeting specific inflammasome components in different cell types will be explored to determine their exact contribution to the metastatic cascade. Moreover, this project will provide a comprehensive functional analysis of specific triggers and downstream effects of the inflammasome in a cell type specific manner in the TME during metastasis formation.
Main Collaborations
- P01 Greten: Modulating CAF plasticity to enable immunotherapy of colorectal cancer:
- P03 Briquez/Fichtner-Feigl/Reuten: Metastasis predisposing extracellular matrix architecture in colorectal cancer:
- P10 Bengsch/Feuerstein: Targeting the intra-metastatic microbiome in colorectal cancer:
- P16 Fichtner-Feigl/Imkeller: The role of primary-CRC-derived adaptive immune cells in anti-metastasis immunity:
- S01 Berlin/Greten/Naschberger: Human tumor organoid biobanks for preclinical validation:
- S02 Reiss/Ritter: Spatial profiling of the tumor microenvironment in CRC:
- S03 Börries/Gupta: Research Information Infrastructure, Data Management and Bioinformatics Core:
