Specific role(s) of the inflammasome in the TME of primary and metastasized sporadic CRC
Research Focus
P07 will specifically examine the contribution of inflammasomes that act as intracellular danger-sensing complex controlling release of pro-inflammatory cytokines belonging to the IL-1 family. Various genetic models targeting specific inflammasome components in different cell types will be explored to determine their exact contribution to the metastatic cascade. Moreover, this project will provide a comprehensive functional analysis of specific triggers and downstream effects of the inflammasome in a cell type specific manner in the TME during metastasis formation.
Main Collaborations
- P01 Greten: Modulating CAF plasticity to enable immunotherapy of colorectal cancer:
- P03 Briquez/Fichtner-Feigl/Reuten: Metastasis predisposing extracellular matrix architecture in colorectal cancer:
- P10 Bengsch/Feuerstein: Targeting the intra-metastatic microbiome in colorectal cancer:
- P16 Fichtner-Feigl/Imkeller: The role of primary-CRC-derived adaptive immune cells in anti-metastasis immunity:
- S01 Berlin/Greten/Naschberger: Human tumor organoid biobanks for preclinical validation:
- S02 Reiss/Ritter: Spatial profiling of the tumor microenvironment in CRC:
- S03 Börries/Gupta: Research information infrastructure, data management and bioinformatics core:
Core Team
Publications
Partial hepatectomy accelerates colorectal metastasis by priming an inflammatory premetastatic niche in the liver
Luenstedt J, Hoping F, Feuerstein R, Mauerer B, Berlin C, Rapp J, Marx L, Reichardt W, von Elverfeldt D, Ruess DA, Plundrich D, Laessle C, Jud A, Neeff HP, Holzner PA, Fichtner-Feigl S, Kesselring R.
Front Immunol. 2024 Jun 10;15:1388272. doi: 10.3389/fimmu.2024.1388272. eCollection 2024. PMID: 38919609
Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage 4 colorectal cancer
Berlin C, Mauerer B, Cauchy P, Luenstedt J, Sankowski R, Marx L, Feuerstein R, Schaefer L, Greten FR, Pesic M, Groß O, Prinz M, Ruehl N, Miketiuk L, Jauch D, Laessle C, Jud A, Biesel EA, Neeff H, Fichtner-Feigl S, Holzner PA, Kesselring R.
Clin Invest. 2023 Dec 28;134(5):e169576. doi: 10.1172/JCI169576. PMID: 38153787