P04
Mapping the CAF subtype-dependent reciprocal signaling in the CRC niche
Research Focus
Continuing a successful joint effort between Erlangen and Frankfurt established in RU 2438 P04 examines the function of CAF-tumor bidirectional signaling. Zeb1-mediated CAF diversification increases anti-tumor immunity and promotes tumor progression towards metastasis. Taking advantage of well-established human and murine co-culture systems and genetic mouse models, this project aims to map the CAF subtype-specific secretomes and explore the TME-tumor crosstalk using a novel niche-labeling approach. Ultimately, interfering with Zeb1-dependent mediators may enable immune checkpoint inhibition.
Main Collaborations
- P01 Greten: Modulating CAF plasticity to enable immunotherapy of colorectal cancer:
- P03 Briquez/Fichtner-Feigl/Reuten: Metastasis predisposing extracellular matrix architecture in colorectal cancer:
- P05 Neufert: The role of LIFR signaling in CAFs in CRC:
- P07 Berlin/Groß: Specific role(s) of the inflammasome in the TME of primary and metastasized sporadic CRC:
- S01 Berlin/Greten/Naschberger: Human tumor organoid biobanks for preclinical validation:
- S02 Reiss/Ritter: Spatial profiling of the tumor microenvironment in CRC:
- S03 Börries/Gupta: Research Information Infrastructure, Data Management and Bioinformatics Core:
