P03
Metastasis predisposing extracellular matrix architecture in colorectal cancer
Research Focus
© GSH
P03 aims to follow the hypothesis that stiffness of baseline basement membrane (basM), a specialized type of the ECM, determines metastasis formation independently of cancer type or underlying mutational profile. Preliminary data suggest that the ratio of netrin-4 and laminin may be responsible for alterations in matrix pore size and stiffness. The concept of stiffness-dependent metastasis formation and the potential contribution of netrin-4 will be assessed in relevant preclinical models and primary human samples.
Main Collaborations
- P01 Greten: Modulating CAF plasticity to enable immunotherapy of colorectal cancer:
- P02 Büttner/Flinner: Multi modal prediction of therapy response for rectal cancer patients:
- P06 Günther/Naschberger: Impact of vascular plasticity on therapy responses in CRC:
- P10 Bengsch/Feuerstein: Targeting the intra-metastatic microbiome in colorectal cancer:
- S01 Berlin/Greten/Naschberger: Human tumor organoid biobanks for preclinical validation:
- S02 Reiss/Ritter: Spatial profiling of the tumor microenvironment in CRC:
- S03 Börries/Gupta: Research Information Infrastructure, Data Management and Bioinformatics Core:
