P08
The role of IL-38 in shaping tumor-promoting versus protective inflammation in colorectal cancer
Project Leader
Research Focus
© A. Weigert
IL-38 is a member of the IL-1 family that confers important functions in the resolution of inflammatory processes. P08 will evaluate the notion that targeting IL-38 could be a valuable approach to enhance anti-tumor immunity in CRC potentially also sensitizing for immunotherapy. While various cell types in the colorectal TME upregulate IL-38 expression, their exact contribution and the respective downstream signaling events in IL-38 responsive cells are only partially understood. To identify the relevant target cells, cytotoxic lymphocytes will be analyzed by Phenoptics multispectral imaging and multicolor flow cytometry.
Main Collaborations
- P01 Greten: Modulating CAF plasticity to enable immunotherapy of colorectal cancer:
- P05 Neufert: The role of LIFR signaling in CAFs in CRC:
- P07 Berlin/Groß: Specific role(s) of the inflammasome in the TME of primary and metastasized sporadic CRC:
- P09 Koop/Neurath: Unraveling the Role of Stromal IL-36R Signaling in Colorectal Tumorigenesis:
- P14 Kesselring/Minguet: The role of γδ T cells in the tumor microenvironment of colorectal cancer:
- P16 Fichtner-Feigl/Imkeller: The role of primary-CRC-derived adaptive immune cells in anti-metastasis immunity:
- P18 Buchholz/Farin: Identifying and overcoming CAR T cell barriers in the colorectal carcinoma microenvironment:
- S01 Berlin/Greten/Naschberger: Human tumor organoid biobanks for preclinical validation:
- S02 Reiss/Ritter: Spatial profiling of the tumor microenvironment in CRC:
- S03 Börries/Gupta: Research Information Infrastructure, Data Management and Bioinformatics Core:
Core Team
