P12
Identification of immunomodulatory microbial metabolites as novel therapeutics for advanced CRC
Project Leader
Research Focus
The composition of the microbiome has been documented to be very different in mice kept under SPF conditions and animals with microbes from wild mice (so-called wildlings) leading to distinct immune responses and disease outcome. P12 hypothesizes that in contrast to SPF-housed mice wildling microbiota will protect from CRC development and aims therefore to systematically compare the impact of such different microbiota on tumor progression and development of metastasis.
Main Collaborations
- P01 Greten: Modulating CAF plasticity to enable immunotherapy of colorectal cancer:
- P06 Günther/Naschberger: Impact of vascular plasticity on therapy responses in CRC:
- P07 Berlin/Groß: Specific role(s) of the inflammasome in the TME of primary and metastasized sporadic CRC:
- P10 Bengsch/Feuerstein: Targeting the intra-metastatic microbiome in colorectal cancer:
- P11 Arkan/Tatarova: Role of microbial amino acid metabolism on chemotherapy response in CRC:
- P13 Müller/Zundler: Modulation of CRC development and progression by GPR15L-dependent effects on lymphocyte infiltration and the intestinal microbiota:
- P14 Kesselring/Minguet: The role of γδ T cells in the tumor microenvironment of colorectal cancer:
- P16 Fichtner-Feigl/Imkeller: The role of primary-CRC-derived adaptive immune cells in anti-metastasis immunity:
- S02 Reiss/Ritter: Spatial profiling of the tumor microenvironment in CRC:
- S03 Börries/Gupta: Research Information Infrastructure, Data Management and Bioinformatics Core:
Core Team
candidate has been recruited
Publications
- Laboratory mice born to wild mice have natural microbiota and model human immune responses.
Rosshart SP, Herz J, Vassallo BG, Hunter A, Wall MK, Badger JH, McCulloch JA, Anastasakis DG, Sarshad AA, Leonardi I, Collins N, Blatter JA, Han SJ, Tamoutounour S, Potapova S, Foster St Claire MB, Yuan W, Sen SK, Dreier MS, Hild B, Hafner M, Wang D, Iliev ID, Belkaid Y, Trinchieri G, Rehermann B. Science. 2019 Aug 2;365(6452):eaaw4361. doi: 10.1126/science.aaw4361. Epub 2019 Aug 1. PMID: 31371577
- Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance.
Rosshart SP, Vassallo BG, Angeletti D, Hutchinson DS, Morgan AP, Takeda K, Hickman HD, McCulloch JA, Badger JH, Ajami NJ, Trinchieri G, Pardo-Manuel de Villena F, Yewdell JW, Rehermann B. Cell. 2017 Nov 16;171(5):1015-1028.e13. doi: 10.1016/j.cell.2017.09.016. Epub 2017 Oct 19. PMID: 29056339