P17
STAT3-controlled cross-dressing of dendritic cells in anti-tumor immunity
Project Leader
Research Focus
Based on the observation that during tumor initiation mitophagy in intestinal epithelial cells enhances antigen presentation and cross dressing of dendritic cells, P17 aims to examine the exact impact of cross dressing and the molecular mechanisms involved in shaping anti-tumor immunity. The specific properties of MHC-I bound antigens transferred by cross dressing will be analyzed by affinity tag-based purification and subsequent LC–MS/MS and compared to all MHCI-I bound antigens and the potential contribution of cross dressing for immunotherapy will be evaluated.
Main Collaborations
- P01 Greten: Modulating CAF plasticity to enable immunotherapy of colorectal cancer:
- P02 Büttner/Flinner: Multi modal prediction of therapy response for rectal cancer patients:
- P03 Briquez/Fichtner-Feigl/Reuten: Metastasis predisposing extracellular matrix architecture in colorectal cancer:
- P04 Farin/Stemmler: Mapping the CAF subtype-dependent reciprocal signaling in the CRC niche:
- P06 Günther/Naschberger: Impact of vascular plasticity on therapy responses in CRC:
- P15 Hildner: Tumor stroma-derived signals impair cDC1-dependent checkpoint inhibition as a potential resistance mechanism of colorectal cancer immunotherapy:
- P16 Fichtner-Feigl/Imkeller: The role of primary-CRC-derived adaptive immune cells in anti-metastasis immunity:
- P18 Buchholz/Farin: Identifying and overcoming CAR T cell barriers in the colorectal carcinoma microenvironment:
- S02 Reiss/Ritter: Spatial profiling of the tumor microenvironment in CRC:
- S03 Börries/Gupta: Research Information Infrastructure, Data Management and Bioinformatics Core:
Core Team
