Publications
2026
Fibroblast dynamics in colorectal cancer: stability, plasticity, and novel markers
Demmler R, Anchang CG, Yong Y, Ramming A, Rauber S, Schellerer VS, Schmid B, Hartmann A, Merkel S, Imkeller K, Naschberger E, Stürzl M.
Oncogene. 2026 Jul;45(24):2299-2312. doi: 10.1038/s41388-026-03809-6. Epub 2026 Apr 28. PMID: 42050076.
Pathophysiology of colitis-associated colorectal cancer
Neufert C, Neurath MF.
Nat Rev Gastroenterol Hepatol. 2026 Jul;23(7):549-562. doi: 10.1038/s41575-026-01197-6. Epub 2026 Apr 1. PMID: 41922722.
The endogenous peptide GPR15L shapes the intestinal microbiota to counteract colitis
Leggio M, Schramm S, Dietz L, Ocón B, Wirtz S, Puertolas Balint F, Yilmaz B, Petzold J, Liu LJ, Dedden M, Ekici A; TRR241 IBDome Consortium; Meng X, Bingham D, Ullrich KA, Heltmann-Meyer S, Günther C, Hildner K, Atreya R, Atreya I, Müller TM, Gerlach RG, Schroeder BO, Macpherson A, Butcher EC, Neurath MF, Zundler S; TRR241 IBCome Consortium.
Gut. 2026 Jun 25:gutjnl-2025-337619. doi: 10.1136/gutjnl-2025-337619. Epub ahead of print. PMID: 42209192.
2025
Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures
Cakmak P, Lun JH, Singh A, Macas J, Schupp J, Schuck J, Mahmoud Z, Köhler M, Starzetz T, Burger MC, Steidl E, Hasse LM, Hattingen E, Plate KH, Reiss Y, Imkeller K.
Immunity. 2025 Oct 21:S1074-7613(25)00429-7. doi: 10.1016/j.immuni.2025.09.018.
Identification and characterization of tertiary lymphoid structures in brain metastases
Mughal SS, Reiss Y, Felsberg J, Meyer L, Macas J, Schlue S, Starzetz T, Köhrer K, Fehm T, Müller V, Lamszus K, Schadendorf D, Helfrich I, Wikman H, Berghoff A, Brors B, Plate KH, Reifenberger G.
Acta Neuropathol Commun. 2025 May 3;13(1):91. doi: 10.1186/s40478-025-02007-x.
Spatial single-cell profiling and neighbourhood analysis reveal the determinants of immune architecture connected to checkpoint inhibitor therapy outcome in hepatocellular carcinoma
Salié H, Wischer L, D'Alessio A, Godbole I, Suo Y, Otto-Mora P, Beck J, Neumann O, Stenzinger A, Schirmacher P, Fulgenzi CAM, Blaumeiser A, Boerries M, Roehlen N, Schultheiß M, Hofmann M, Thimme R, Pinato DJ, Longerich T, Bengsch B.
Gut. 2025 Feb 6;74(3):451-466. doi: 10.1136/gutjnl-2024-332837. PMID: 39349005
2024
Partial hepatectomy accelerates colorectal metastasis by priming an inflammatory premetastatic niche in the liver
Luenstedt J, Hoping F, Feuerstein R, Mauerer B, Berlin C, Rapp J, Marx L, Reichardt W, von Elverfeldt D, Ruess DA, Plundrich D, Laessle C, Jud A, Neeff HP, Holzner PA, Fichtner-Feigl S, Kesselring R.
Front Immunol. 2024 Jun 10;15:1388272. doi: 10.3389/fimmu.2024.1388272. eCollection 2024. PMID: 38919609
Glioma-associated tertiary lymphoid structures are sites of lymphocyte clonal expansion and plasma cell formation
Pinar Cakmak, Jennifer H. Lun, Aakanksha Singh, Jadranka Macas, Jonathan Schupp, Miriam Köhler, Tatjana Starzetz, Michael C. Burger, Eike Steidl, Lucie Marie Hasse, Elke Hattingen, Karl H. Plate, Yvonne Reiss, Katharina Imkeller
2008 – 2023
Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage 4 colorectal cancer
Berlin C, Mauerer B, Cauchy P, Luenstedt J, Sankowski R, Marx L, Feuerstein R, Schaefer L, Greten FR, Pesic M, Groß O, Prinz M, Ruehl N, Miketiuk L, Jauch D, Laessle C, Jud A, Biesel EA, Neeff H, Fichtner-Feigl S, Holzner PA, Kesselring R.
Clin Invest. 2023 Dec 28;134(5):e169576. doi: 10.1172/JCI169576. PMID: 38153787
Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma
Burger MC, Forster MT, Romanski A, Straßheimer F, Macas J, Zeiner PS, Steidl E, Herkt S, Weber KJ, Schupp J, Lun JH, Strecker MI, Wlotzka K, Cakmak P, Opitz C, George R, Mildenberger IC, Nowakowska P, Zhang C, Röder J, Müller E, Ihrig K, Langen KJ, Rieger MA, Herrmann E, Bonig H, Harter PN, Reiss Y, Hattingen E, Rödel F, Plate KH, Tonn T, Senft C, Steinbach JP, Wels WS.
Neuro Oncol. 2023 Nov 2;25(11):2058-2071. doi: 10.1093/neuonc/noad087.
Interleukin 36 receptor-inducible matrix metalloproteinase 13 mediates intestinal fibrosis
Koop K, Enderle K, Hillmann M, Ruspeckhofer L, Vieth M, Sturm G, Trajanoski Z, Kühl AA, Atreya R, Leppkes M, Baum P, Roy J, Martin A, Neurath MF, Neufert C.
Front Immunol. 2023 May 3;14:1163198. doi: 10.3389/fimmu.2023.1163198. eCollection 2023. PMID: 37207229
The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response
Schuhwerk H, Kleemann J, Gupta P, van Roey R, Armstark I, Kreileder M, Feldker N, Ramesh V, Hajjaj Y, Fuchs K, Mahapatro M, Hribersek M, Volante M, Groenewoud A, Engel FB, Ceppi P, Eckstein M, Hartmann A, Müller F, Kroll T, Stemmler MP, Brabletz S, Brabletz T.
Cell Rep. 2022 Dec 13;41(11):111819. doi: 10.1016/j.celrep.2022.111819. PMID: 36516781
T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma
Barsch M, Salié H, Schlaak AE, Zhang Z, Hess M, Mayer LS, Tauber C, Otto-Mora P, Ohtani T, Nilsson T, Wischer L, Winkler F, Manne S, Rech A, Schmitt-Graeff A, Bronsert P, Hofmann M, Neumann-Haefelin C, Boettler T, Fichtner-Feigl S, van Boemmel F, Berg T, Rimassa L, Di Tommaso L, Saeed A, D'Alessio A, Pinato DJ, Bettinger D, Binder H, John Wherry E, Schultheiss M, Thimme R, Bengsch B.
J Hepatol. 2022 Aug;77(2):397-409. doi: 10.1016/j.jhep.2022.02.032. Epub 2022 Apr 1. PMID: 35367533
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
Nicolas AM, Pesic M, Engel E, Ziegler PK, Diefenhardt M, Kennel KB, Buettner F, Conche C, Petrocelli V, Elwakeel E, Weigert A, Zinoveva A, Fleischmann M, Häupl B, Karakütük C, Bohnenberger H, Mosa MH, Kaderali L, Gaedcke J, Ghadimi M, Rödel F, Arkan MC, Oellerich T, Rödel C, Fokas E, Greten FR.
Cancer Cell. 2022 Feb 14;40(2):168-184.e13. doi: 10.1016/j.ccell.2022.01.004. Epub 2022 Feb 3. PMID: 35120600
Spatially confined sub-tumor microenvironments in pancreatic cancer
Grünwald BT, Devisme A, Andrieux G, Vyas F, Aliar K, McCloskey CW, Macklin A, Jang GH, Denroche R, Romero JM, Bavi P, Bronsert P, Notta F, O'Kane G, Wilson J, Knox J, Tamblyn L, Udaskin M, Radulovich N, Fischer SE, Boerries M, Gallinger S, Kislinger T, Khokha R.
Cell. 2021 Oct 28;184(22):5577-5592.e18. doi: 10.1016/j.cell.2021.09.022. Epub 2021 Oct 12. PMID: 34644529
IL-36 in chronic inflammation and cancer
Neurath MF.
Cytokine Growth Factor Rev. 2020 Oct;55:70-79. doi: 10.1016/j.cytogfr.2020.06.006. Epub 2020 Jun 7. PMID: 32540133
Laboratory mice born to wild mice have natural microbiota and model human immune responses
Rosshart SP, Herz J, Vassallo BG, Hunter A, Wall MK, Badger JH, McCulloch JA, Anastasakis DG, Sarshad AA, Leonardi I, Collins N, Blatter JA, Han SJ, Tamoutounour S, Potapova S, Foster St Claire MB, Yuan W, Sen SK, Dreier MS, Hild B, Hafner M, Wang D, Iliev ID, Belkaid Y, Trinchieri G, Rehermann B.
Science. 2019 Aug 2;365(6452):eaaw4361. doi: 10.1126/science.aaw4361. Epub 2019 Aug 1. PMID: 31371577
Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance
Rosshart SP, Vassallo BG, Angeletti D, Hutchinson DS, Morgan AP, Takeda K, Hickman HD, McCulloch JA, Badger JH, Ajami NJ, Trinchieri G, Pardo-Manuel de Villena F, Yewdell JW, Rehermann B.
Cell. 2017 Nov 16;171(5):1015-1028.e13. doi: 10.1016/j.cell.2017.09.016. Epub 2017 Oct 19. PMID: 29056339
IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo
Scheibe K, Backert I, Wirtz S, Hueber A, Schett G, Vieth M, Probst HC, Bopp T, Neurath MF, Neufert C.
Gut. 2017 May;66(5):823-838. doi: 10.1136/gutjnl-2015-310374. Epub 2016 Jan 18. PMID: 26783184
Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer
Punkenburg E, Vogler T, Büttner M, Amann K, Waldner M, Atreya R, Abendroth B, Mudter J, Merkel S, Gallmeier E, Rose-John S, Neurath MF, Hildner K.
Gut. 2016 Jul;65(7):1139-50. doi: 10.1136/gutjnl-2014-308227. Epub 2015 Apr 2. PMID: 25838550