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Publications

2026

Fibroblast dynamics in colorectal cancer: stability, plasticity, and novel markers

Demmler R, Anchang CG, Yong Y, Ramming A, Rauber S, Schellerer VS, Schmid B, Hartmann A, Merkel S, Imkeller K, Naschberger E, Stürzl M.

Oncogene. 2026 Jul;45(24):2299-2312. doi: 10.1038/s41388-026-03809-6. Epub 2026 Apr 28. PMID: 42050076. 

Pathophysiology of colitis-associated colorectal cancer

Neufert C, Neurath MF.

Nat Rev Gastroenterol Hepatol. 2026 Jul;23(7):549-562. doi: 10.1038/s41575-026-01197-6. Epub 2026 Apr 1. PMID: 41922722.

The endogenous peptide GPR15L shapes the intestinal microbiota to counteract colitis

Leggio M, Schramm S, Dietz L, Ocón B, Wirtz S, Puertolas Balint F, Yilmaz B, Petzold J, Liu LJ, Dedden M, Ekici A; TRR241 IBDome Consortium; Meng X, Bingham D, Ullrich KA, Heltmann-Meyer S, Günther C, Hildner K, Atreya R, Atreya I, Müller TM, Gerlach RG, Schroeder BO, Macpherson A, Butcher EC, Neurath MF, Zundler S; TRR241 IBCome Consortium.

Gut. 2026 Jun 25:gutjnl-2025-337619. doi: 10.1136/gutjnl-2025-337619. Epub ahead of print. PMID: 42209192.

2025

Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures

Cakmak P, Lun JH, Singh A, Macas J, Schupp J, Schuck J, Mahmoud Z, Köhler M, Starzetz T, Burger MC, Steidl E, Hasse LM, Hattingen E, Plate KH, Reiss Y, Imkeller K

Immunity. 2025 Oct 21:S1074-7613(25)00429-7. doi: 10.1016/j.immuni.2025.09.018.

Identification and characterization of tertiary lymphoid structures in brain metastases

Mughal SS, Reiss Y, Felsberg J, Meyer L, Macas J, Schlue S, Starzetz T, Köhrer K, Fehm T, Müller V, Lamszus K, Schadendorf D, Helfrich I, Wikman H, Berghoff A, Brors B, Plate KH, Reifenberger G. 

Acta Neuropathol Commun. 2025 May 3;13(1):91. doi: 10.1186/s40478-025-02007-x.

Spatial single-cell profiling and neighbourhood analysis reveal the determinants of immune architecture connected to checkpoint inhibitor therapy outcome in hepatocellular carcinoma

Salié H, Wischer L, D'Alessio A, Godbole I, Suo Y, Otto-Mora P, Beck J, Neumann O, Stenzinger A, Schirmacher P, Fulgenzi CAM, Blaumeiser A, Boerries M, Roehlen N, Schultheiß M, Hofmann M, Thimme R, Pinato DJ, Longerich T, Bengsch B

Gut. 2025 Feb 6;74(3):451-466. doi: 10.1136/gutjnl-2024-332837. PMID: 39349005

2024

Partial hepatectomy accelerates colorectal metastasis by priming an inflammatory premetastatic niche in the liver

Luenstedt J, Hoping F, Feuerstein R, Mauerer B, Berlin C, Rapp J, Marx L, Reichardt W, von Elverfeldt D, Ruess DA, Plundrich D, Laessle C, Jud A, Neeff HP, Holzner PA, Fichtner-Feigl S, Kesselring R. 

Front Immunol. 2024 Jun 10;15:1388272. doi: 10.3389/fimmu.2024.1388272. eCollection 2024. PMID: 38919609

Glioma-associated tertiary lymphoid structures are sites of lymphocyte clonal expansion and plasma cell formation

Pinar Cakmak, Jennifer H. Lun, Aakanksha Singh, Jadranka Macas, Jonathan Schupp, Miriam Köhler, Tatjana Starzetz, Michael C. Burger, Eike Steidl, Lucie Marie Hasse, Elke Hattingen, Karl H. Plate, Yvonne Reiss, Katharina Imkeller 

doi: doi.org/10.1101/2024.07.04.602038

2008 – 2023

Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage 4 colorectal cancer

Berlin C, Mauerer B, Cauchy P, Luenstedt J, Sankowski R, Marx L, Feuerstein R, Schaefer L, Greten FR, Pesic M, Groß O, Prinz M, Ruehl N, Miketiuk L, Jauch D, Laessle C, Jud A, Biesel EA, Neeff H, Fichtner-Feigl S, Holzner PA, Kesselring R. 

Clin Invest. 2023 Dec 28;134(5):e169576. doi: 10.1172/JCI169576. PMID: 38153787

Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma

Burger MC, Forster MT, Romanski A, Straßheimer F, Macas J, Zeiner PS, Steidl E, Herkt S, Weber KJ, Schupp J, Lun JH, Strecker MI, Wlotzka K, Cakmak P, Opitz C, George R, Mildenberger IC, Nowakowska P, Zhang C, Röder J, Müller E, Ihrig K, Langen KJ, Rieger MA, Herrmann E, Bonig H, Harter PN, Reiss Y, Hattingen E, Rödel F, Plate KH, Tonn T, Senft C, Steinbach JP, Wels WS. 

Neuro Oncol. 2023 Nov 2;25(11):2058-2071. doi: 10.1093/neuonc/noad087.

Interleukin 36 receptor-inducible matrix metalloproteinase 13 mediates intestinal fibrosis

Koop K, Enderle K, Hillmann M, Ruspeckhofer L, Vieth M, Sturm G, Trajanoski Z, Kühl AA, Atreya R, Leppkes M, Baum P, Roy J, Martin A, Neurath MF, Neufert C. 

Front Immunol. 2023 May 3;14:1163198. doi: 10.3389/fimmu.2023.1163198. eCollection 2023. PMID: 37207229

The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response

Schuhwerk H, Kleemann J, Gupta P, van Roey R, Armstark I, Kreileder M, Feldker N, Ramesh V, Hajjaj Y, Fuchs K, Mahapatro M, Hribersek M, Volante M, Groenewoud A, Engel FB, Ceppi P, Eckstein M, Hartmann A, Müller F, Kroll T, Stemmler MP, Brabletz S, Brabletz T. 

Cell Rep. 2022 Dec 13;41(11):111819. doi: 10.1016/j.celrep.2022.111819. PMID: 36516781

T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma

Barsch M, Salié H, Schlaak AE, Zhang Z, Hess M, Mayer LS, Tauber C, Otto-Mora P, Ohtani T, Nilsson T, Wischer L, Winkler F, Manne S, Rech A, Schmitt-Graeff A, Bronsert P, Hofmann M, Neumann-Haefelin C, Boettler T, Fichtner-Feigl S, van Boemmel F, Berg T, Rimassa L, Di Tommaso L, Saeed A, D'Alessio A, Pinato DJ, Bettinger D, Binder H, John Wherry E, Schultheiss M, Thimme R, Bengsch B

J Hepatol. 2022 Aug;77(2):397-409. doi: 10.1016/j.jhep.2022.02.032. Epub 2022 Apr 1. PMID: 35367533

Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer

Nicolas AM, Pesic M, Engel E, Ziegler PK, Diefenhardt M, Kennel KB, Buettner F, Conche C, Petrocelli V, Elwakeel E, Weigert A, Zinoveva A, Fleischmann M, Häupl B, Karakütük C, Bohnenberger H, Mosa MH, Kaderali L, Gaedcke J, Ghadimi M, Rödel F, Arkan MC, Oellerich T, Rödel C, Fokas E, Greten FR.

Cancer Cell. 2022 Feb 14;40(2):168-184.e13. doi: 10.1016/j.ccell.2022.01.004. Epub 2022 Feb 3. PMID: 35120600

Spatially confined sub-tumor microenvironments in pancreatic cancer

Grünwald BT, Devisme A, Andrieux G, Vyas F, Aliar K, McCloskey CW, Macklin A, Jang GH, Denroche R, Romero JM, Bavi P, Bronsert P, Notta F, O'Kane G, Wilson J, Knox J, Tamblyn L, Udaskin M, Radulovich N, Fischer SE, Boerries M, Gallinger S, Kislinger T, Khokha R. 

Cell. 2021 Oct 28;184(22):5577-5592.e18. doi: 10.1016/j.cell.2021.09.022. Epub 2021 Oct 12. PMID: 34644529

IL-36 in chronic inflammation and cancer

Neurath MF. 

Cytokine Growth Factor Rev. 2020 Oct;55:70-79. doi: 10.1016/j.cytogfr.2020.06.006. Epub 2020 Jun 7. PMID: 32540133

Laboratory mice born to wild mice have natural microbiota and model human immune responses

Rosshart SP, Herz J, Vassallo BG, Hunter A, Wall MK, Badger JH, McCulloch JA, Anastasakis DG, Sarshad AA, Leonardi I, Collins N, Blatter JA, Han SJ, Tamoutounour S, Potapova S, Foster St Claire MB, Yuan W, Sen SK, Dreier MS, Hild B, Hafner M, Wang D, Iliev ID, Belkaid Y, Trinchieri G, Rehermann B. 

Science. 2019 Aug 2;365(6452):eaaw4361. doi: 10.1126/science.aaw4361. Epub 2019 Aug 1. PMID: 31371577 

Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance

Rosshart SP, Vassallo BG, Angeletti D, Hutchinson DS, Morgan AP, Takeda K, Hickman HD, McCulloch JA, Badger JH, Ajami NJ, Trinchieri G, Pardo-Manuel de Villena F, Yewdell JW, Rehermann B. 

Cell. 2017 Nov 16;171(5):1015-1028.e13. doi: 10.1016/j.cell.2017.09.016. Epub 2017 Oct 19. PMID: 29056339

IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo

Scheibe K, Backert I, Wirtz S, Hueber A, Schett G, Vieth M, Probst HC, Bopp T, Neurath MF, Neufert C. 

Gut. 2017 May;66(5):823-838. doi: 10.1136/gutjnl-2015-310374. Epub 2016 Jan 18. PMID: 26783184

Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer

Punkenburg E, Vogler T, Büttner M, Amann K, Waldner M, Atreya R, Abendroth B, Mudter J, Merkel S, Gallmeier E, Rose-John S, Neurath MF, Hildner K. 

Gut. 2016 Jul;65(7):1139-50. doi: 10.1136/gutjnl-2014-308227. Epub 2015 Apr 2. PMID: 25838550